45 ACP +P ammo is externally/dimensionally identical to 45 ACP ammo and can be fired in any 45 ACP firearm that is in normal operating condition. However, the greater pressures and power of the +P ammo will give you greater slide velocity and if you are going to shoot more than a box or two of +P ammo, you should consider replacing your recoil spring with a Wolf Spring that gives roughly 4 to 6 lb more spring weight than factory stock springs. A shock buffer might also be a good addition although it is not too necessary if you use the stronger spring.