When it comes to smokeless powder, Ramshot Big Game Shotshell/Handgun Powder is an outstanding option. This is a newly manufactured product, which means the powder is not from military surplus nor has it been extracted from loaded ammunition. In addition, the powder has a spherical shape and is double based. Other benefits associated with this powder include excellent velocities, incredible case fill for consistent shooting, and unrivaled performance that is highly popular for various calibers, including .22-250 Remington. The powder burns clean and offers great properties for metering.