One Shot Ultra 8 is for vaccination of healthy cattle as an aid in preventing blackleg caused by Clostridium chauvoei, malignant edema caused by Cl. septicum, bacillary hemoglobinuria caused by Cl. haemolyticum, black disease caused by Cl. novyi, gas-gangrene caused by Cl. sordellii, enterotoxemia and enteritis caused by Cl. perfringens types B, C, and D, and bovine pneumonia caused by Mannheimia (Pasteurella) haemolytica type A1. Although Cl. perfringens type B is not a significant problem in North America, immunity is provided by the beta toxoid of type C and the epsilon toxoid of type D. The freeze-dried component is a preparation of inactivated whole cultures of M. haemolytica propagated to increase the production of leukotoxin and capsular and cell-associated antigens. The liquid component consists of killed, standardized cultures of Cl. chauvoei, Cl. septicum, Cl. haemolyticum, Cl. novyi, Cl. sordellii, and Cl. perfringens types C and D, with a special, water-soluble adjuvant (Stimugen) to enhance the immune response. Uses: Aids in the prevention of diseases caused by the clostridial agents (Clostridium chauvoei, Cl. septicum, Cl. haemolyticum, Cl. novyi, Cl. sordellii, Cl. perfringens types B, C and D) and bovine pneumonia caused by Mannheimia haemolytica Type A1.Efficacy of One Shot Ultra 8 against M. haemolytica was demonstrated in a challenge-of-immunity study. Cattle (300-550 lb) vaccinated with one dose of One Shot Ultra 8 were subjected to severe experimental challenge at two weeks post vaccination with a heterologous strain of M. haemolytica type A1. Four days post-challenge, animals were necropsied and individual lungs were evaluated for lung damage and lesions characteristic of M. haemolytica type A1 infection. Vaccinates demonstrated a statistically significant reduction (82.6%) in lung damage compared to animals receiving a placebo. Immunogenicity of the clostridial fractions was confirmed by serologic studiesKey Features: Helps prevent eight clostridial diseases (including diseases caused by CI. haemolyticum and CI perfringens Types B, C, and D), which continue to be of economic importance in cattle. Clostridium bacteria are universally present and produce potent toxins that can result in rapid death of otherwise healthy animals. Helps protect against the primary cause of respiratory death in cattle, shipping fever and pneumonia caused by Mannheimia haemolytica Type A1.Produces leukotoxin and whole-cell antibody responses, helping provide protection needed to withstand Mannheimia haemolytica challenge. Contains Stimugen(R), a patented, water-soluble adjuvant that enhances the immune response with minimal risk of injection-site reactions. No age restrictions on use. Subcutaneous (SC) dose is 2 mL followed by a second 2-mL dose of UltraChoice(R) 8 four to six weeks later. For CI. haemolyticum, repeat the dose every six months in animals subject to re-exposure. | Zoetis ONE SHOT ULTRA 8 Cattle Vaccine | Size 10 Dose